Ethics code: IR.IAU.RASHT.REC.1401.009
Clinical trials code: IRCT20220821055765N1
1- Rasht Branch, Islamic Azad University
Abstract: (7 Views)
Abstract
Background & Objectives: Increasing age and decreasing estrogen levels in postmenopausal women cause obesity, increased body fat, and decreased skeletal muscle mass due to hormonal changes and body composition. Physical activity as a potential intervention strategy can lead to improvement of muscle strength and reduction of obesity in preventing and overcoming post-menopausal complications. It was shown that low to moderate intensity exercise could result in a decrease in blood levels of hs-CRP and improvement in cardiorespiratory endurance of postmenopausal women. On the other hand, menopause increases the risk of muscle damage and the occurrence of oxidative stress, which leads to chronic inflammatory diseases, so antioxidant compounds can help in the prevention and treatment of inflammatory disorders and reduction of the creatine-phosphokinase secretion. Exercises with Tribulus supplement may be an effective method to control menopausal complications in overweight women. The present study aimed to determine the effect of a combined aerobic-resistance exercise with tribulus supplement on creatine-phosphokinase (CPK), lactate-dehydrogenase (LDH), and hs-CRP in overweight postmenopausal women.
Methods: The present study was a quasi-experimental with pretest and posttest design with a control group. The statistical sample comprised 60 eligible postmenopausal women aged 50-65 from Rasht city. The inclusion criteria were overweight, cessation of menstruation for more than 12 consecutive months, age range between 55 and 65 years, not using hormone therapy in the past one year, not smoking in the previous 6 months, and complaining of some menopausal complications. Exclusion criteria were any injury during the research, unwillingness, or absenteeism in training sessions for three consecutive sessions. They were randomly divided into four equal groups: inactive control, moderate intensity training, supplement group, and combined (moderate intensity training with supplement consumption) groups. Groups 2 and 4 performed exercise training program for 10 weeks. Moderate intensity training was included walking and running on a treadmill and resistance training was performed with an elastic band, including Exercises include 9 movements bench press, squat, biceps curl, seated row, knee bend, sit-up, knee extension, overhead press, and bench press. The supplement was taken as 500 mg capsules twice a day by groups 3 and 4. Research variables were measured before and after 10 weeks. The data were analyzed using the analysis of variance test with repeated measurements in SPSS version 25 software at a significance level of 0.05.
Results: The results showed that there was a significant difference between the four groups in the variables of fat percentage, CPK, LDH, and hs-CRP (P<0.001). The follow-up test results showed a significant difference between the training and supplement groups in the CPK indices (p=0.005) and between the two supplement and combination groups in the LDH (p=0.009). In addition, the hs-CRP variable showed a significant difference between the three experimental groups and the control group (P<0.001), but there was no difference between the experimental groups.
Conclusion: In total, the results of the present study showed that 10 weeks of combined exercises with Tribulus supplement decreased LDH, CPK and hs-CRP in overweight postmenopausal women. So, postmenopausal women with overweight could utilize combined exercises with Tribulus supplement to improve muscle and inflammatory indicators.
Background & Objectives: Increasing age and decreasing estrogen levels in postmenopausal women cause obesity, increased body fat, and decreased skeletal muscle mass due to hormonal changes and body composition. Physical activity as a potential intervention strategy can lead to improvement of muscle strength and reduction of obesity in preventing and overcoming post-menopausal complications. It was shown that low to moderate intensity exercise could result in a decrease in blood levels of hs-CRP and improvement in cardiorespiratory endurance of postmenopausal women. On the other hand, menopause increases the risk of muscle damage and the occurrence of oxidative stress, which leads to chronic inflammatory diseases, so antioxidant compounds can help in the prevention and treatment of inflammatory disorders and reduction of the creatine-phosphokinase secretion. Exercises with Tribulus supplement may be an effective method to control menopausal complications in overweight women. The present study aimed to determine the effect of a combined aerobic-resistance exercise with tribulus supplement on creatine-phosphokinase (CPK), lactate-dehydrogenase (LDH), and hs-CRP in overweight postmenopausal women.
Methods: The present study was a quasi-experimental with pretest and posttest design with a control group. The statistical sample comprised 60 eligible postmenopausal women aged 50-65 from Rasht city. The inclusion criteria were overweight, cessation of menstruation for more than 12 consecutive months, age range between 55 and 65 years, not using hormone therapy in the past one year, not smoking in the previous 6 months, and complaining of some menopausal complications. Exclusion criteria were any injury during the research, unwillingness, or absenteeism in training sessions for three consecutive sessions. They were randomly divided into four equal groups: inactive control, moderate intensity training, supplement group, and combined (moderate intensity training with supplement consumption) groups. Groups 2 and 4 performed exercise training program for 10 weeks. Moderate intensity training was included walking and running on a treadmill and resistance training was performed with an elastic band, including Exercises include 9 movements bench press, squat, biceps curl, seated row, knee bend, sit-up, knee extension, overhead press, and bench press. The supplement was taken as 500 mg capsules twice a day by groups 3 and 4. Research variables were measured before and after 10 weeks. The data were analyzed using the analysis of variance test with repeated measurements in SPSS version 25 software at a significance level of 0.05.
Results: The results showed that there was a significant difference between the four groups in the variables of fat percentage, CPK, LDH, and hs-CRP (P<0.001). The follow-up test results showed a significant difference between the training and supplement groups in the CPK indices (p=0.005) and between the two supplement and combination groups in the LDH (p=0.009). In addition, the hs-CRP variable showed a significant difference between the three experimental groups and the control group (P<0.001), but there was no difference between the experimental groups.
Conclusion: In total, the results of the present study showed that 10 weeks of combined exercises with Tribulus supplement decreased LDH, CPK and hs-CRP in overweight postmenopausal women. So, postmenopausal women with overweight could utilize combined exercises with Tribulus supplement to improve muscle and inflammatory indicators.
Type of Study: Original Research Article |
Subject:
Rehabilitation
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